Survey Of Pharmacological Activity And Pharmacokinetics Of Selected Beta-Adrenergic Blockers In Regard To Their Stereochemistry

The present survey concentrates on pharmacodynamics and pharmacokinetics of selected beta-adrenergic blockers from the point of view of their stereochemistry. It could be shown that the activity in the arylaminoethanol and aryloxyaminopropanol group of beta-blockers is higher in their (-)-enantiomers as compared with the (+)-enantiomers. The stereoisomers differ also in other types of bioactivity as well as in toxicity. The particular pharmacokinetic stages such as resorption, distribution, and metabolism are discussed in regard to their stereochemistry.