P.1.10 Long-term down-regulation of BDNF in association with exposure to stress early in life: The role of miR-583

Buildings consume a considerable share of global energy, mostly from non-renewable sources, and emit a substantial amount of CO2. As this is not aligned with sustainable development goals one of the main changes needed is to make buildings more energy efficient by insulating them from the ambient environment. This article discusses the factors affecting the type and quantity of insulating materials in a residential building made using prefabricated Structural Insulated Panels (SIPs), and designed to require near zero space conditioning. A life cycle assessment approach is used to find the most effective level of insulation. The analysis shows it is not appropriate to use the same type of SIPs in different locations, as some relevant factors are context-dependent. The factors considered in this analysis were the design goals, climate characteristics, and most importantly the current and projected profile of the energy used for manufacturing materials and for operating the building. It is important these factors are studied together, as individual investigations can be misleading.