Enantioselective One-Pot Synthesis of Biaryl-SubstitutedAmines by Combining Palladium and Enzyme Catalysis in Deep EutecticSolvents
ACS Sustainable Chemistry & Engineering(2019)
Abstract
The first application of Deep Eutectic Solvents (DESs) in asymmetric bioamination of ketones has been accomplished. The amine transaminases (ATAs) turned out to be particularly stable in DES-buffer mixtures at a percentage of up to 75% (w/w) neoteric solvent. Moreover, this reaction medium was used to perform a chemoenzymatic cascade toward biaryl amines by coupling a Suzuki reaction sequentially with an enantioselective bioamination catalyzed by the recently discovered ATA from Exophiala xenobiotica (EX-ωTA). The solubilizing properties of DESs enabled the metal-catalyzed step at 200 mM loading of substrate and the subsequent biotransformation at 25 mM.
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Key words
Amines,Asymmetric synthesis,Biocatalysis,Deep eutectic solvents,Palladium catalysis,Suzuki cross-coupling reaction
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