Abstract 15090: Circulating miR-503 and miR-374b-5p are associated With Heart Failure

Introduction: Circulating microRNA (miRNAs) profiles are dysregulated in heart failure (HF) suggesting possible diagnostic and prognostic applications. In addition, miRNAs may yield insights into the pathophysiology of HF and provide targets for therapeutic intervention. We sought to identify miRNAs diagnostic utility in HF and to further investigate selected miRNAs as potential targets for therapeutic intervention. Hypothesis: We hypothesized that distinct circulating miRNAs are dysregulated in HF and may be potentially important targets of therapy to improve outcomes for HF. Methods: Plasma miRNAs levels were profiled from 338 well-characterized HF patients and 208 age-matched controls without HF. We also examined selected miRNAs expression in a rat post-myocardial infarction (MI) model. Target predictive databases were used to identify potential miRNA targets. Results: Comparison between HF and non-HF controls was carried out by multivariate analysis. Seventy five miRNAs differed significantly between ...