Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis

Event Abstract Back to Event Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis Elise Peyre1*, Carla S. Gomes Da Silva1*, Mohit H. Adhikari2, Sylvia Tielens1, Nathalie Krusy1, Sebastian Tanco3, Petra Van Damme3, Lorenza Magno4, Maria Magiera5, Nicoletta Kessaris4, Brigitte Malgrange1, Annie Andrieux6, Carsten Janke5 and Laurent Nguyen1* 1 Giga neurosciences, Belgium 2 Center for Brain and Cognition, Information and Technology, Spain 3 VIB-UGent, Center for Medical Biotechnologie, Belgium 4 Wolfson Institute for Biomedical Research, Cell and Developmental Biology, University College, United Kingdom 5 Institut Curie, CNRS UMR3348, PSL Research University, Centre Universitaire, Orsay,, France 6 Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Inserm, U1216, France Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo saltatory migration, which is paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. However, it remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes deglutamylation, is a pivotal regulator of pausing of migrating cortical interneurons. Moreover, we show that pausing during migration attenuates movement simultaneity at the population level thereby controlling the flow of interneurons invading the cortex. Keywords: interneuron, Migration, corticogenesis, Deglutamylation, CCP1 Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Development Citation: Peyre E, Gomes Da Silva CS, Adhikari MH, Tielens S, Krusy N, Tanco S, Van Damme P, Magno L, Magiera M, Kessaris N, Malgrange B, Andrieux A, Janke C and Nguyen L (2019). Cell-intrinsic regulation of interneuron migration controls cortical neurogenesis. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00039 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Dr. Elise Peyre, Giga neurosciences, Liège, 4000, Belgium, e.peyre@ulg.ac.be Dr. Carla S Gomes Da Silva, Giga neurosciences, Liège, 4000, Belgium, cgomesdasilva@ulg.ac.be Dr. Laurent Nguyen, Giga neurosciences, Liège, 4000, Belgium, lnguyen@ulg.ac.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elise Peyre Carla S Gomes Da Silva Mohit H Adhikari Sylvia Tielens Nathalie Krusy Sebastian Tanco Petra Van Damme Lorenza Magno Maria Magiera Nicoletta Kessaris Brigitte Malgrange Annie Andrieux Carsten Janke Laurent Nguyen Google Elise Peyre Carla S Gomes Da Silva Mohit H Adhikari Sylvia Tielens Nathalie Krusy Sebastian Tanco Petra Van Damme Lorenza Magno Maria Magiera Nicoletta Kessaris Brigitte Malgrange Annie Andrieux Carsten Janke Laurent Nguyen Google Scholar Elise Peyre Carla S Gomes Da Silva Mohit H Adhikari Sylvia Tielens Nathalie Krusy Sebastian Tanco Petra Van Damme Lorenza Magno Maria Magiera Nicoletta Kessaris Brigitte Malgrange Annie Andrieux Carsten Janke Laurent Nguyen PubMed Elise Peyre Carla S Gomes Da Silva Mohit H Adhikari Sylvia Tielens Nathalie Krusy Sebastian Tanco Petra Van Damme Lorenza Magno Maria Magiera Nicoletta Kessaris Brigitte Malgrange Annie Andrieux Carsten Janke Laurent Nguyen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.