Abstract 17786: Epinephrine Administration (EA) During Cardiopulmonary Resuscitation (CPR) Increases Cerebral Tissue Oxygen Saturation: Study With Pulse-observing Mode of Near-infrared Spectroscopy

Introduction: Recently, the effectiveness of the EA during CPR has been questioned. For some time, we have been analyzing the cerebral tissue oxygen saturation observed during CPR. During AHA 2014, we reported the possibility that an increase in the cerebral tissue oxygenation index (TOI) would predict the recovery of spontaneous circulation (ROSC). This time, we report the results of our clinical study about the relationship between the EA and changes in TOI. Methods: In 59 patients undergoing out-of-hospital cardiac arrest, the blood pulsation waveform and TOI in the brain were continuously monitored with the NIRO-200NX system (Hamamatsu Photonics K.K., Japan) using its pulse-observing mode (NIRO-Pulse mode). The total number of EAs was 86 and, as shown in the figure, the initial and terminal TOIs in the CPR before EA (2 minutes) and the initial and terminal TOIs in the CPR after EA (2 minutes) were measured. Results: The initial and terminal TOIs before EA were 37.6±7.2% and 40.0±7.2% respectively, and...