Asymmetric synthesis of the cytotoxic lactone (+)-cardiobutanolide and two novel analogues

Ivana Kovačević,Mirjana Popsavin,Marko V. Rodić,Vesna Kojić,Velimir Popsavin

Tetrahedron Letters（2019）

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摘要

•A new total synthesis of cardiobutanolide and two new analogues has been completed.•In vitro antitumour activity of this natural product and analogues was recorded.•(+)-Cardiobutanolide was identified as the most active compound.

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关键词

Cardiobutanolide,Analogues,Styryl lactones,Antitumour agents,Asymmetric synthesis

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