Enantiomeric O,O-dimenthyl α-iminotrifluoroethylphosphonates: Novel chiral building blocks in asymmetric synthesis of α-trifluoromethylated α-aminophosphonic acid derivatives

•Synthesis of novel chiral synthons, O,O-dimenthyl α-iminotrifluoroethylphosphonates, was developed.•Double asymmetric induction on OAB-catalyzed reduction of scalemic iminophosphonates.•Diastereoselective proline-catalyzed Mannich reaction of α-iminophosphonates with acetone.•Diastereoselective introduction of α-CF3-α-aminophosphonic fragment into pyrroles and indole.•Diastereoselective aza-Henry reaction of scalemic α-iminotrifluoroethylphosphonates.