Treatment of Stage IV Rectal Cancer: A Multicentre Study on Short-Course Radiotherapy Followed by Neoadjuvant Systemic Therapy and Subsequent Surgical Treatment
European journal of surgical oncology(2019)
摘要
Background. The optimal treatment strategy for rectal cancer patients with synchronous liver metastases remains under debate. Short-course pelvic radiotherapy (5x5 Gy) followed by systemic therapy and subsequent surgical treatment of all tumour sites, as performed in the Dutch M1-study, combines optimal local control of the rectal tumour with the immediate start of systemic therapy and could offer long-term survival. This Dutch multicentre study reports long-term oncological and surgical outcome of patients treated with the M1-schedule in daily practice.
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