A multi-stage supply chain network design problem with in-house production and partial product outsourcing

•Study of a 4-stage supply chain network design problem combining in-house production and product outsourcing.•MILP model for facility location, procurement, production, distribution, transportation mode choice, and external sourcing.•Analysis of the value of product outsourcing through modeling two alternative strategies for network design.•Discussion of extensive numerical results, including useful managerial insights on network design and logistics functions.