Fungi-derived lipopeptide antibiotics developed since 2000

Peptides(2019)

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摘要
•Members of fungi are an important source of lipopeptide products.•Lipopeptides exhibit potent activity against human and plant pathogens.•Four distinctive categories of fungi-derived lipopeptides are reported.•Antibiotic activity, SARs, mechanisms of action and specific relevance are discussed.•Eight derivatives have been developed into commercial products or clinical trials.
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关键词
Fungi,Lipopeptide,Depsipeptide,Peptaibiotic,Structure-activity relationship,Mechanism of action
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