Structural insights into biofilm polysaccharide de-N-acetylation in the fungus Aspergillus fumigatus

Natalie Bamford,Francois Le Mauff,Hanna Ostapska,Don Sheppard, Lynne Howell

Acta Crystallographica Section A（2018）

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摘要

Aspergillus fumigatus is an opportunistic fungal pathogen that causes acute and chronic invasive infections.The exopolysaccharide galactosaminogalactan (GAG) is a virulence factor essential for A. fumigatus biofilm formation.GAG aids in host immune evasion, adherence to tissue and

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