P125 MIR-21-5P AND MIR-146A-5P ARE DEREGULATED IN INFLAMED TERMINAL ILEUM OF TREATMENT-NAÏVE PEDIATRIC PATIENTS WITH CROHN’S DISEASE

Deregulation of intestinal microRNAs (miRNAs) have been reported in adult and, in the last years, also in pediatric patients with Crohn’s disease (CD). We performed a literature search and chose 4 miRNAs from five relevant studies as candidates for an independent validation (miR-21-5p, miR-31-5p, miR-146a-5p, miR-155-5p). The goal of this study was to verify deregulated expression of the candidate miRNAs in inflamed terminal ileum of treatment-naïve pediatric patients with CD.