An Amino-Chain Modified Beta-Cyclodextrin: A Supramolecular Ligand For Pd(Oac)2 Acceleration In Suzuki-Miyaura Coupling Reactions In Water

A well-designed and synthesized water-soluble class of beta-cyclodextrin supported palladium complex PdLn@Et-beta-CD could efficiently validate high catalytic activity and act as a supramolecular platform for phosphine-free Suzuki-Miyaura cross-coupling reactions between arylboronic acid/arylboronic ester and aryl halides in water under mild conditions. The presented novel PdLn@Pr-beta-CD complex catalyst was characterized by NMR, XRD, FT-IR, and DSC analysis. Furthermore, the role of the PdLn@Et-beta-CD fragment in the reaction mechanism studied by molecular complexation was proposed based on FT-IR, 2D NMR (ROESY) spectroscopy, FE-SEM, and DSC spectroscopic analysis. The important benefits of this technique comprise simple phosphine-free preparation of the palladium catalyst, a wide range of functional-group tolerance, and easy recyclability; this method, furthermore, eschews hazardous reagents or solvents.