Total synthesis of natural (−)- and unnatural (+)-Melearoride A

Tetrahedron Letters(2019)

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摘要
•First total synthesis of (−)-Melearoride A.•Total synthesis of (+)-Melearoride A.•A concise 13 step synthesis from chiral pool starting materials.•High yielding RCM to close the 13-membered macrocycle.
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关键词
Melearoride A,Total synthesis,Macrolides,Asymmetric alkylation
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