Bioelectronics At The Single Molecule Level

O. Tolga Gul,Kaitlin M. Pugliese,Yongki Choi,Arith J. Rajapakse,Calvin J. Lau,Narendra Kumar,Kristin N. Gabriel,Denys Marushchak,Tivoli J. Olsen,Deng Pan,Gregory A. Weiss,Philip G. Collins

2018 IEEE INTERNATIONAL ELECTRON DEVICES MEETING (IEDM)（2018）

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Abstract

Bioelectronic devices built with single molecules of a protein, enzyme, or aptamer represent a new class of hybrid electronics. When biofunctionalization of nanoscale conductors is reduced to one molecule, that molecule's dynamic activity can be transduced into a large amplitude, high bandwidth electronic output. Using DNA polymerase I as an example, we show that single-molecule bioelectronics reveal biochemical activity with bond-by-bond resolution.

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Key words

dynamic activity,high bandwidth electronic output,single-molecule bioelectronics,single molecule level,bioelectronic devices,single molecules,enzyme,aptamer,hybrid electronics,nanoscale conductors

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