Anti-Mycobacterium tuberculosis activity of dichloromethane extract of Piper corcovadensis (Miq.) C. DC. roots and isolated compounds

Carla M.M. Fernandez,Vanessa P. Baldin,Andressa L. Ieque, Karine Z. Bernuci,Rafaela T. Almeida, Larissa M. Valone,Dyenefer P. Fonseca, Regina Y. Makimori, João Paulo P. Andrade,Eduardo J. Pilau,Mariza B. Romagnolo,Tania U. Nakamura,Rosilene F. Cardoso,Diógenes A.G. Cortez,Zilda C. Gazim,Regiane B.L. Scodro,Benedito P. Dias Filho

Industrial Crops and Products（2019）

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摘要

•Crude extract of Piper corcovadensis roots and isolated compounds exhibited anti-Mycobacterium tuberculosis activity.•Crude extract of Piper corcovadensis roots and isolated compounds in combination with rifampicin showed synergism.•Isolated compounds showed selectivity index greater than 20 for Mycobacterium tuberculosis.•Crude extract of Piper corcovadensis roots and isolated compounds presented activity for clinical isolates resistant.•Crude extract of Piper corcovadensis roots and isolated compounds showed promising in vitro results for the development of new drugs.

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关键词

Piper corcovandensis,Piperovatine,Piperlonguminine,Isopiperlonguminine,Mycobacterium tuberculosis,REMA

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