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Pharmacological strategies to lower crosstalk between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and mitochondria

Nirmala Koju,Abdoh Taleb,Jifang Zhou,Ge Lv,Jie Yang,Xian Cao,Hui Lei,Qilong Ding

Biomedicine & Pharmacotherapy（2019）

Cited 40|Views8
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Abstract
•Oxidative stress involves excess ROS generation and reduced antioxidant capacity.•Crosstalk between NADPH oxidase and mitochondria is bidirectional.•Crosstalk between sources of ROS may be one of the promising targets for drug development.
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Key words
Oxidative stress,Endothelial dysfunction,ROS induced ROS release (RIRR),Antioxidant defense system
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