Host Lipids in Positive-Strand RNA Virus Genome Replication
FRONTIERS IN MICROBIOLOGY(2019)
摘要
Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.
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关键词
lipid metabolism,phospholipids,membrane association,positive-strand RNA virus,viral RNA replication
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