The Biological Activity of Extracts of Marine Invertebrates from Troitsa Bay (Sea of Japan)

— The biological activity of extracts from nine species of marine invertebrates (the phyla Cnidaria, Annelida, Sipunculida, and Nemertea) that inhabit Troitsa Bay (Peter the Great Bay, Sea of Japan) was determined using in vitro and in vivo models. It was found that extracts of marine worms, that is, the polychaete Eularia viridis and sipunculida Phascolostoma agassizii , have an antibacterial effect and reduce the adhesion of macrophages, whereas extracts of the jellyfish Gonionemus vertens exhibit neurotoxic effects and are also able to increase or decrease the adhesion of macrophages, depending on the method of extraction. These marine animals can be a source of antimicrobial, antioxidant, antitumor, and immunostimulating compounds.