Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity.

Janine Häfliger,Marlene Schwarzfischer,Kirstin Atrott,Claudia Stanzel,Yasser Morsy,Marcin Wawrzyniak,Silvia Lang,Tomas Valenta,Konrad Basler,Gerhard Rogler,Michael Scharl,Marianne R Spalinger

Gastroenterology（2023）

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摘要

Our work shows that GP96 plays a fundamental role in regulating ISC fate and epithelial regeneration and therefore is indispensable for maintaining intestinal epithelial homeostasis.

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关键词

ER Stress,Intestinal Stem Cells,LRP6,Notch Signaling,Wnt Signaling

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