Accumulation and Elimination Kinetics of 2-Methylisoborneol in Crucian Carp ( Carassius carassius )

2-methylisoborneol (2-MIB) is a common, earthy-smelling compound that causes taste and odor issues in aquaculture. To quantify the distribution, absorption, and depuration of 2-MIB in crucian carp ( Carassius carassius ), we detected and measured 2-MIB it via microwave, headspace solid-phase microextraction (HS-SPME), and gas chromatography before and after exposing fish to two different concentrations of 2-MIB (200 ng/L and 500 ng/L). The results showed that during the exposure time, the fish absorbed 2-MIB rapidly within 4 h. After exposure to 2-MIB for 120 h, the 2-MIB in gill and liver were rapidly removed. The processes of accumulation and elimination of 2-MIB in fish were investigated using the one-compartment kinetic model. The modeling results showed that the range of the uptake rate constant ( k 1 ) was 0.49-6.91. The range of the elimination rate constant ( k 2 ) was 0.05-0.27 and uptake rates were higher than elimination rates. The bioconcentration factor (BCF) was estimated according to the physicochemical properties of 2-MIB, and the bioaccumulation of 2-MIB in fish had a close correlation with the octanol/water partition coefficient ( K ow ).