Neural stem cell niche heterogeneity

Julia P. Andreotti,Walison N. Silva,Alinne C. Costa,Caroline C. Picoli, Flávia C.O. Bitencourt,Leda M.C. Coimbra-Campos,Rodrigo R. Resende,Luiz A.V. Magno,Marco A. Romano-Silva,Akiva Mintz,Alexander Birbrair

Seminars in Cell & Developmental Biology（2019）

Cited 75|Views56

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Abstract

•Neural stem cells are not equally plastic homogeneous cells, but rather a combination of distinct subpopulations.•The cerebrospinal fluid is an essential component of the neural stem cell niche.•Neural stem cells auto-regulate themselves.•Innervations release neurotransmitters to neural stem cells, and affect neural stem cell behavior.•The biggest challenge remains to study the neural stem cell niche in humans.

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Key words

3V,ARC,CD133,CD15,CD24,CD81,CD9,Cre,CreER,CSF,DCX,DG,DMH,DREADDs,EGFR,ERT2,FGF-2,GABA,GABAergic,GCL,GFAP,Glast,Gli1,IGF-1,L-DOPA,LHA,LoxP,ME,Mfge8,mRNA,mTOR1,NeuN,NG2,NSC,PSA-NCAM,PVH,RGLs,RNA,RNAseq,SGZ,SGZ,Sox1,SVZ,Tie2,VE-Cadherin,VEGF,VIP,VMH,Wnt,α-SYN

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