Polynuclear neutrophil variation and oxidative stress in Type 2 Diabetics

Context: Chronic hyperglycemia and inflammation in type 2 diabetics may be correlated with oxidative stress, which is the basis of micro-and macro-angiopathic complications.The evolution of this inflammation resulted in the accumulation of neutrophils at the inflammatory site, the latter are in the basal state in a state of constant preactivation for the production of O2 0-.Objectives: This study aimed to determine the quantitative and morphological variation of neutrophils; and to identify the level of correlation between neutrophil levels and oxidative stress in type 2 diabetics in Lubumbashi.Material and methods: Spectrophotometric and microscopic methods were used to evaluate glycemia and neutrophils in the samples.Results: The study included 27 confirmed type 2 diabetics, including 52% of women.Their average age was 56.33 ± 11.79 years old.An increase in neutrophil count and a deviation of the Arneth curve were observed in 37.03% and 71.14%, respectively, of diabetic subjects.Conclusion: This study showed an increase in neutrophils in type 2 diabetics.This may be related to an indirect activation of the immune system in these subjects.