Gastric-acid-mediated drug–drug interactions with direct-acting antiviral medications for hepatitis C virus infection: clinical relevance and mitigation strategies

•Gastric-acid-mediated drug–drug interaction (DDI) liability and clinical significance for DAA medications have been systemically analyzed.•Assessments of gastric-acid-related DDIs can be confounded by meal intake conditions.•In well-designed, dedicated DDI studies, confounding factors are balanced or controlled, providing reliable information on DDIs associated with gastric acid suppression.•Priorities for prospective DDI studies for assessment of such interactions in early-phase clinical development are warranted.