Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II

Jaehyoun Lee,J. Brooks Crickard,Joseph C. Reese,Tae-Hee Lee

Methods（2019）

引用 17|浏览8

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摘要

•The method enables investigation of transcription dynamics through the nucleosome.•The method is based on single-molecule FRET in a highly refined in vitro system.•The method measures RNAPII nucleosomal pause frequencies and durations.•The method measures RNAPII elongation rates within the nucleosome.

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关键词

Single-molecule FRET,Transcription elongation,RNA polymerase II,Nucleosome

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