Wound healing models: A systematic review of animal and non-animal models

Chronic wounds and ulcers are a significant challenge to researchers and healthcare providers. Research into the area of wound care is in great need due to the increase in incidence and healthcare cost. Wound healing models are essential to test new therapeutics, study the pathogenesis of the tissue repair mechanism and to detect new biomarkers. The aim of this review is to provide an overview for currently available animal and non-animal wound healing models.