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3D cell coculture tumor model: A promising approach for future cancer drug discovery

Xin Xin,Hopen Yang,Fengli Zhang,Shang-Tian Yang

Process Biochemistry（2019）

Cited 35|Views9
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Abstract
•Multiple stromal cell types play vital roles in tumor initiation, growth, and metastasis.•Coculturing cancer and stromal cells can better mimic tumor microenvironment.•In vitro studies of tumor-stromal cell interactions in cocultures are summarized.•Application of 3D cocultures for high throughput screening of cancer drugs is discussed.
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Key words
Cancer,Microenvironment,3D cell culture,Coculture,Cancer drug screening,High throughput screening,Tumor stroma
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