Glycan-modified interfaces in biosensing: an electrochemical approach

Glycans (complex carbohydrates) attached to various interfacial layers represent a simple but functional model of a cellular surface, which is covered densely by glycans. In this review, we discuss interactions of surface-confined glycans with various glycan-binding proteins, viruses, or pathogenic bacteria. Such glycan receptive interfaces can be applied for biosensing of these analytes. In this review, we focus on the application of glycan interfaces for label-free electrochemical biosensing.