Impact Of Nutrition Status And Systematic Inflammation On Patients With Colorectal Cancer

e14648 Background: Cancer progression and patient prognosis have reportedly some association with systemic inflammation and nutritional status of individual patient. We investigate the impact of Prognostic Nutritional Index (PNI), modified Glasgow prognostic score (mGPS) and neutrophil or platelet lymphocyte ratio on prognosis of colorectal cancer. Methods: Three-hundred-forty patients were performed tumor free curative resection between January 2006 and December 2012. Patients with neoadjuvant chemotherapy or metastatic colon cancer were excluded from this study. Factors associated with cancer recurrence and patients survival were assessed by univariate and multivariate analysis Results: In univariate analysis, preoperative levels of albumin and CRP, mGPS, PNI were found factors statisticaly associated with both disease free survival (DFS) and overall survival (OS) after surgery, besides lymph node metastasis, lymphatic and vascular invasion. Multivariate analysis showed mGPS other than lymph node metastasis were independent factors associated with DFS and OS. Conclusions: Systemic inflammation and malnutrition are highly prevalent in patients with colorectal cancer and they have significant impact on their survival.