An Accessible and Unique Insight into Metastasis Mutational Content Through Whole-exome Sequencing of Circulating Tumor Cells in Metastatic Prostate Cancer
European Urology Oncology(2020)
Abstract
Genomic analysis of circulating tumor cells (CTCs) can provide a unique insight into metastasis mutational diversity and reveal undiagnosed aberrations in matched metastasis biopsies from patients with castration-resistant prostate cancer. Our findings emphasize the clinical potential of detection of such aberrations in CTCs via minimally invasive blood draws.
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Key words
Circulating tumor cells,Liquid biopsy,Prostate cancer,Whole-exome sequencing
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