Protective effects of olive in renal failure; a review on current knowledge

Context: The pathogenesis of renal damage as a risk factor of renal failure can be due to oxidative stress resulting from an imbalance between the production of free radicals and antioxidants. Therefore, antioxidant therapy can be a good strategy to decrease the effects of such diseases. Hence, the aim of this review was to evaluate the protective effect of olive oil as an herb rich in antioxidant compounds on kidney damage in previous studies. Evidence Acquisitions: Present review is based on scrutinizing the contents of relevant papers searched in PubMed, Google Scholar, EBSCO, Embase, directory of open access journals (DOAJ), Web of Science and Scopus. Results: Numerous studies have introduced herbal treatments, being rich sources of antioxidants, as appropriate alternatives for several diseases, including renal damage, when considering the pathogenesis of the diseases. The olive has also been recommended as a plant that has different therapeutic effects, and its therapeutic effects on the kidneys are mentioned in several studies, including the reduction of renal damage parameters and an increase in the antioxidant power of enzymes in the body. Conclusions: Considering the numerous studies on animal models, particularly rats and renal cell lines, olive oil can be used as a reliable method for the treatment of various kidney damages. However, further studies are also recommended in humans.