Abstract P200: Night Sleep Duration and Hypertension in Chinese Rural Population: The Henan Rural Cohort Study

Aim: The purpose of the study was to evaluate the association between night sleep duration and hypertension, and to examine whether the mediation effect of night sleep duration and hypertension exists in rural population based on the factors of blood lipids. Methods: Night sleep duration was classified into <5h, 5-h, 6-h, 7-h, 8-h, 9-h and ≥10h. Logistic regression and restricted cubic spline were performed to evaluate the association of night sleep duration with hypertension. Mediation analysis was used to explore the mediation effect of night sleep duration and hypertension. Results: Among the 37, 317 participants, a total of 12, 333 suffered from hypertension. Compared with reference, fully-adjusted OR of hypertension, undiagnosed and diagnosed hypertension were 1.52(1.25-1.84), 1.68(1.32-2.14) and 1.32(1.03-1.69) respectively among male sleeping for 10h at night. Additionally, the dose-response relationship of night sleep duration with prevalent hypertension risk was also found in male (Figure 1, P <0.05). Mediation analyses showed that the OR for hypertension among male (total effect, 1.089; 95% CI , 1.040, 1.139). Low density lipoprotein cholesterol (LDL-C) showing the OR , 1.003(95% CI , 1.001, 1.005) for indirect effect and 1.085(1.038, 1.137) for direct effect partly mediated their association. Conclusion: A dose-response association of night sleep duration and hypertension was found in male but not in female. Additionally, LDL-C mediated the association between night sleep duration and hypertension among male. Figure 1. Relation of night sleep duration for hypertension from restricted cubic splines.