A facile metal-free approach to N,N′-bis(1-oxidopyrimidin-4-yl)diamines with promising biological activity

Kseniya N. Sedenkova,Anna A. Nazarova,Evgeny V. Khvatov,Evgenia V. Dueva,Alexey A. Orlov,Dmitry I. Osolodkin,Yuri K. Grishin,Tamara S. Kuznetsova,Vladimir A. Palyulin,Elena B. Averina

Mendeleev Communications（2018）

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摘要

Novel N-(1-oxidopyrimidin-4-yl)- and N,N′-bis(1-oxidopyrimidin-4-yl)diamines were prepared from 4-fluoropyrimidine N-oxides and diamines basing on SNAr reaction. One compound from this series possessed antiviral activity against tick-borne encephalitis virus (TBEV).

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