Biological Function and Molecular Mechanism of piRNA in cancer

Ghanbar Mahmoodi Chalbatani,Hassan Dana,Feridon Memari,Elahe Gharagozlou, Shirin Ashjaei,Peyman Kheirandish,Vahid Marmari,Habibollah Mahmoudzadeh, Farnaz Mozayani,Ali Reza Maleki,Ehsan Sadeghian, Elham Zainali Nia,Seyed Rohollah Miri, Neda zainali Nia,Omid Rezaeian, Anahita Eskandary, Narges Razavi,Mohammad Shirkhoda,Fatemeh Nouri Rouzbahani

Practical Laboratory Medicine（2019）

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摘要

Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

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关键词

Cancer,PiRNA,Noncoding RNA,Gene silencing,RNAi

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