Fabrication and characterization of 3D-printed biocomposite scaffolds based on PCL and silanated silica particles for bone tissue regeneration

•Composite scaffolds consisting of PCL and silanated silica particles were proposed for bone tissue regeneration.•The composite scaffolds were fabricated using a simple melt-blending method and a melt-3D printing process.•The composite scaffolds showed remarkable physical properties.•The composite scaffolds produced significant osteogenic differentiation results.