Cirrhosis induced by thioacetamide is prevented by stevia. Molecular mechanisms

Erika Ramos-Tovar,Sael Casas-Grajales,Erika Hernández-Aquino,Rosa E. Flores-Beltrán,Silvia Galindo-Gómez,Eunice Vera-Aguilar,Araceli Diaz-Ruiz,Sergio Montes,Javier Camacho,Víctor Tsutsumi,Pablo Muriel

Journal of Functional Foods（2019）

引用 9|浏览6

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摘要

•Stevia rebaudiana leaves prevent experimental cirrhosis.•Stevia upregulates the Nrf2 endogenous antioxidant system.•Stevia blocks the canonical and non-canonical TGF-β1 profibrotic pathway.•Stevia prevents HSC activation and collagen deposition.•Stevia maintains normal striatal dopamine turnover, suggesting its potential to treat hepatic encephalopathy.

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关键词

Liver,Sweetener,Stevioside,Anti-inflammatory,Fibrosis

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