Arylsubstituted Halogen(Thiocyanato) Amides Containing 4-Acetylphenyl Fragment. Synthesis, Cyclization And Antimicrobial Properties

CHEMISTRY & CHEMICAL TECHNOLOGY(2018)

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Abstract
3-(4-Acetylphenyl)-(2-methyl)-2-chloro(bromo, thiocyanato) propanamides have been obtained via copper catalytic anionarylation of acrylic and methacrylic acids amides by 4-acetylphenyldiazonium salts. 5-(4-Acetylphenyl) substituted 2-aminothiazol-4(5H)-ones were synthesized by cyclisation of thiocyanatoamides. All synthesized compounds were tested for their antibacterial and antomycotic activity.
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Key words
anionarylation, acrylic and methacrylic acids amides, 4-acetylphenyldiazonium salts, 5-arylsubstituted 2-aminothiazol-4(5H)-ones, antimicrobial activity
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