Total synthesis of cytotoxic pyranone B
SYNTHETIC COMMUNICATIONS(2018)
Abstract
The first stereoselective total synthesis of cytotoxic diacetylene pyranone B is described. The key steps involved in the synthesis are baseinduced elimination protocol to generate the chiral acetylenic alcohol and selective cross- coupling of unsymmetrical terminal acetylenes. [GRAPHICS] .
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Key words
Diacetylene,cytotoxic,base-induced elimination,Cadiot-Chodkiewicz cross-coupling,Sonogashira cross-coupling
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