Chiral recognition of dihydroxyphenylalanine enantiomers with (R)/(S)-2-Phenylpropionic acid grafted PProDOT electrochemical sensors

Two novel chiral 3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine (ProDOT)-based electrochemical sensor, employing a pair of glassy carbon electrodes modified with chiral poly(2-Phenyl-propionic acid 3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepin-3-ylmethyl ester) (PProDTM-PP), were utilized for the enantioselective detection of chiral 3,4-dihydroxyphenylalanine (DOPA). The enantioselective recognition between chiral PProDTM-PP modified glassy carbon electrodes and chiral DOPA was studied by using different electrochemical technologies. The redox activity and electrochemical stability of chiral PProDTM-PP was good. (R)-PProDTM-PP and (S)-PProDTM-PP showed higher peak current responses toward D-DOPA and L-DOPA, respectively. Furthermore, the recognition efficiencies of chiral PProDTM-PP are between 1.48 and 1.89, which is higher than chiral PEDOT-based electrochemical sensors (around 1.10). The chiral PProDTM-PP provides an alternative to chiral recognition.