Synthesis, characterization and antibacterial activity of Methyl (2R)-2-benzamido-2-{[(1R)-2-methoxy-2-oxo- 1-phenylethyl]amino}acetate

The present work covers the recent synthetic of methyl ( 2R )-2-benzamido-2-{[( 1R )-2-methoxy-2-oxo-1-phenylethyl]amino}acetate, via N -alkylation of methyl a-azido glycinate N -benzoylated with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1 H-NMR, 13 C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria ( Bacillus subtilis and Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa and Salmonella enteric) . The MIC values confirmed that the title compound had a bactericidal effect against the strains tested.