A Simple Transformation of 1‐(Isoxazol‐3‐yl)ureas to 5‐(2‐oxoalkyl)‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones through Base‐Promoted Boulton‐Katritzky Rearrangement

Jisheng Liu, Chen Chen,Rajendraprasad Kotagiri,Wenqiang Yang,Qian Cai

Advanced Synthesis and Catalysis（2019）

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Abstract

2,4‐Dihydro‐3H‐1,2,4‐triazol‐3‐ones are a class of biologically important heterocycles. A novel and simple synthesis of such structures is developed. The method is through a base‐promoted Boulton‐Katritzky‐type rearrangement of 1‐(isoxazol‐3‐yl)ureas and is highly efficient for the formation of 2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐ones.

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Key words

Boulton-Katritzky Rearrangement,Heterocycles,Ring-Transformation,(1-isoxazol-3-yl)urea,2,4-dihydro-3H-1,2,4-triazol-3-one

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