Exopolysaccharides from Leuconostoc mesenteroides attenuate chronic kidney disease in mice by protecting the intestinal barrier

•Oral leucosaccharides mitigate adenine-induced renal failure in mice.•Leucosaccharides reinforce intestinal barriers by restoring healthful microbiota.•Leucosaccharides prevent uremia, endotoxemia, inflammation, and fibrosis.•Leucosaccharides may also prevent complications such as atherosclerosis.