Glycyrrhizic acid improving the liver protective effect by restoring the composition of Lactobacillus
Journal of Functional Foods(2019)
Abstract
•Glycyrrhizic acid and Glycyrrhetinic acid ameliorate the abnormal status of liver cirrhosis.•Only Glycyrrhizic acid down-regulates the TLR4 and LBP gene expressions, which related to intestinal flora disorder.•Glycyrrhizic acid significantly restores the composition of Lactobacillus.•The bioavailability of Glycyrrhizic acid was probably influenced by microbiome dysbiosis.
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Key words
Glycyrrhizic acid,Glycyrrhetinic acid,Liver cirrhosis,Gut microbiota,16S rRNA sequencing
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