Advancing nonclinical innovation and safety in pharmaceutical testing

Elizabeth J. Baker, Nancy A. Beck,Ellen L. Berg, Helene D. Clayton-Jeter, P. Charukeshi Chandrasekera,J. Lowry Curley, Bruce A. Donzanti,Lorna C. Ewart, Jane M. Gunther,J. Gerry Kenna,Edward L. LeCluyse,Michael N. Liebman, Catherine L. Pugh,Paul B. Watkins,Kristie M. Sullivan

Drug Discovery Today（2019）

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摘要

•Stakeholders are collaborating to integrate human-based nonclinical tests.•Regulatory and policy requirements must change from “animal” data to “nonclinical”.•Increased funding is needed for development and evaluation of human-based tests.•Tissue recovery guidelines will increase access to quality tissues for research.•New and established scientists need training and education in human-based tools.

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