Synthesis and Antibacterial Activity of Novel (4‐Fluorophenyl)(4‐(naphthalen‐2‐yl)‐6‐aryl‐2‐thioxo‐2,3‐dihydropyrimidin‐1(6H)‐yl)methanone Derivatives

A novel series of (4-fluorophenyl)(4-(naphthalen-2-yl)-6-aryl-2-thioxo-2,3-dihydropyrimidin-1(6H)-yl)methanone derivatives were synthesized from reaction of 6-(naphthalen-2-yl)-4-aryl-3,4-dihydropyrimidine-2(1H)-thiones with 4-fluorobenzoylchloride in dichloromethane in the presence of triethylamine. The synthesized compounds were screened for antibacterial activity against Gram positive bacteria, namely, Staphylococcus aureus ATCC25923 and Listeria monocytogenes MTCC657, and Gram negative bacteria, namely, Escherichia coli ATCC25922 and Klebsiella pneumoniae ATCC700603, respectively. Some of the tested compounds showed significant antimicrobial activity.