Cnts-Cooh Paste Electrode For Detection Of Temozolomide

The MWCNTs-COOH Paste Electrode (MCPE) was successfully used to study the electrochemical behavior of temozolomide in 0.2 M H2SO4 solution, phosphate buffer solution (0.1114 PBS, pH 7.4) and 0.1114 NaOH solution by Cyclic Voltammetry (CV) technique. The results exhibit that MCPE can remarkably enhance sensing and elecfrocatalytic activity towards the oxidation and reduction of temozolomide in acidic, neutral, and basic solutions. The effect of the scan rate exhibits the adsorption controlling process. The effect of pH range from 2 to 6 was investigated by cyclic voltammetry technique, from cyclic voltammetry study exhibits the peak current was pH dependent with a slope of 68 mV/pH. The detection limit (LOD)) at MCPE were found to be 0.056 mM,0.069 mM and 0.065 mM in 0.1M H2SO4, 0.1M PBS (pH 7.4) and 0.1M NaOH solutions respectively by Cyclic Voltammefric (CV) technique. Similarly, from Linear Scan Voltammetric (LSV) technique, the detection limits (LOD) were found to be 0.050 mM, 0.021mM and 0.036 mM in acidic, neutral, and basic solution respectively. The proposed method was successfully applied for the determination of temozolomide in the clinical sample.