Tissue Advanced Glycation End-Products In Hypertensive Patients Complicated With Or Without Dm And Cad

Objectives: To evaluate the relationship between tissue advanced glycation end-products with artery elasticity in hypertensive patients with or without diabetes mellitus (DM) and coronary artery disease (CAD). Methods: A total of 157 patients were enrolled, HBP group included 62 hypertensive patients, HBP + DM group included 42 hypertensive patients with DM, HBP + DM + CAD group included 53 hypertensive patients with DM and CAD. NBP group included 32 healthy persons. Carotid-femoral pulse wave velocity (cf-PWV, Complior, France) and tissue AGE (Diagnoptics, The Netherlands) were measured in all enrolled persons. Results: 1. The levels of skin autofluorescence (AF) in groups with hypertension were significantly higher than in NBP group (NBP < HBP < HBP + DM < HBP + DM + CAD, fx1P < 0.01). Compared with hypertensive patients without complications, the levels of skin AF in groups with DM and CAD were significantly higher (HBP < HBP + DM < HBP + DM + CAD, fx1P < 0.01)). 2. The levels of cf-PWV in groups with DM and CAD were significantly higher than in NBP group (NBP < HBP + DM < HBP + DM + CAD, P < 0.05, P < 0.01). Compared with hypertensive patients without complications, the levels of cf-PWV in groups with DM and CAD were significantly higher (P < 0.01). 3. The results of multivariate stepwise regression analysis indicated that the level of skin AF had strong effect on cf-PWV. Conclusion: The level of tissue AGE in hypertensive patients was higher than healthy persons, which was more significant in hypertensive patients complicated with DM and CAD. The level of tissue AGE correlated with the abnormality of arterial elasticity, the higher level of tissue AGE might play important role in evaluating vascular risks.