miR-335-5p has an important role in the progression of gastric cancer by down-regulation of CEACAM5

Abstract Background Due to the lack of suitable biomarker to early diagnosis of gastric cancer patients for effective treatment, nowadays there are many experiment acts to use novel biomarker such as miRNAs to early diagnosis of GC. Methods Peripheral blood specimens were collected before treatment from 113 patients with gastric cancer. The CEACAM5 and miR-335 expression were evaluated by quantitative RT-PCR. Result CEACAM5 mRNA expression was significantly lower in patients with AGC than patients with EGC ( P P  u003e .05). Conclusion Our findings demonstrate a possible relationship between the deregulation of miR-335 and CEACAM5 with GC progression, also miR-335 and CEACAM5 have the potential to recognize the AGC than EGC.