Germinal Centers in Minor Salivary Glands in Sjögren's Syndrome: a Morphological and Immunohistochemical Analyses

Jessica Luana Dos Santos,Karen Cristine Bortoletto,Román Carlos,Fernando Chahud,Bruno Augusto Benevenuto De Andrade,Luciana Yamamoto De Almeida,Jorge Esquiche León

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology（2018）

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摘要

Objective: Some studies have reported a higher proportion of germinal centers (GCs) in major than in minor salivary gland (MSG) biopsies from Sjogren syndrome (SS) patients. Detection of GCs in focal lymphocytic sialadenitis (FLS) of SS appears to be associated with disease severity and risk of lymphoma. The aim of this study was to evaluate a correlation of the frequency of GCs with the focus score (FS) in MSG biopsies of SS.

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